Alpha-1-antitrypsin deficiency and hepatocellular carcinoma.
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چکیده
منابع مشابه
Alpha-1-antitrypsin deficiency and hepatocellular carcinoma.
Forty-two cases of hepatocellular carcinoma (HCC) were examined for the presence of the inclusions of alpha-1-antitrypsin (AAT), which indicate a carrier state for the Pi Z gene. These were found in the non-neoplastic liver tissue of two cases of HCC and in one of the 98 control livers, a difference that is not statistically significant. Typical globules of AAT deficiency were not found in HCC ...
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It has been established that alpha-1-antitrypsin (AAT) deficiency due to the homozygous Pi Z state may give rise to cirrhosis and hepatic fibrosis, although the mechanism whereby this occurs is obscure. Also there are numerous reports of hepatocellular carcinoma (HCC) developing in such cases (Ganrot et al., 1967; Berg and Eriksson, 1972; Eriksson and Hagerstrand, 1974). The position of the het...
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Introduction: α1-antitrypsin deficiency (α1-ATD) is one of the most common genetic disorders in white race, a usual cause of liver disease in children, and hepatopulmonary involvement in children and adult. The aim of this case description is presenting a child with early lung disease without liver parenchymal disorder. Case presentation: We describe a 13 year old boy because of exertional dysp...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 1979
ISSN: 0021-9746
DOI: 10.1136/jcp.32.4.373